Nov 27, 2024
PainExam Podcast Show
Episode Title: Exploring PRP and BMAC in Pain Managemen
Host: David Rosenblum, MD
Release Date: November 27,
2024
Episode Overview:
In this episode of the PainExam Podcast, Dr. David Rosenblum, a New
York-based pain physician, examines the latest research surrounding
Platelet-Rich Plasma (PRP) and Bone Marrow Aspirate Concentrate
(BMAC) in pain management for the knee, shoulder, and spine. Dr.
Rosenblum reviews several key studies, providing insights into the
efficacy of these regenerative treatments and their implications
for clinical practice.
Featured Studies:
1. A Comparison of Functional Outcomes in Rotator Cuff
Repairs Using Adjunctive Bone Marrow Aspirate Concentrate vs. Bone
Marrow Aspirate Concentrate With Platelet-Rich Plasma: A Systematic
Review and Meta-Analysis**
- Authors: Seth J.
Spicer, Sara Soliman, Robert Malek, Mitchell Kaplan, Jensen Clark,
Nicholas Averell, Brandon Goodwin, Richard Jermyn
- Published in: Cureus. 2024 Aug
23;16(8):e67594. doi: 10.7759/cureus.67594
- Summary: This systematic review evaluates the
outcomes of rotator cuff repairs (RCR) using BMAC alone versus BMAC
combined with PRP. The analysis included three studies and found no
significant difference in functional outcomes between the two
groups, suggesting that BMAC alone may be adequate, potentially
reducing costs and resource use.
2. Bone Marrow Aspirate Concentrate
Versus Platelet-Rich Plasma for Treating Knee Osteoarthritis: A
One-Year Non-Randomized Retrospective Comparative Study
- Authors: Abed El-Hakim El-Kadiry, Carlos
Lumbao, Natasha Salame, Moutih Rafei, Riam Shammaa
- Published in: BMC Musculoskeletal
Disorders, 2022.
- Summary: This study compared the
effectiveness of intra-articular BMAC and PRP injections in
patients with knee osteoarthritis (OA). Results indicated that
patients receiving BMAC experienced significant improvements in
pain and functionality scores over 12 months, while the PRP group
showed nonsignificant improvements. BMAC was found to be more
effective than PRP in managing knee OA symptoms.
3. Patients With Knee Osteoarthritis Who Receive
Platelet-Rich Plasma or Bone Marrow Aspirate Concentrate Injections
Have Better Outcomes Than Patients Who Receive Hyaluronic Acid:
Systematic Review and Meta-analysis**
- Authors: John W. Belk, Joseph J.
Lim, Carson Keeter, Patrick C. McCulloch, Darby A. Houck, Eric C.
McCarty, Rachel M. Frank, Matthew J. Kraeutler
- Published in: World
Journal of Stem Cells, 2021.
- Summary: This systematic review
assessed the efficacy of PRP and BMAC compared to hyaluronic acid
(HA) injections for knee OA. The findings demonstrated that both
PRP and BMAC led to significantly better patient-reported outcomes
(PROs) compared to HA, with no significant differences between PRP
and BMAC in terms of effectiveness.
4. Platelet-Rich Plasma vs
Bone Marrow Aspirate Concentrate: An Overview of Mechanisms of
Action and Orthobiologic Synergistic Effects
- Authors: José Fábio Santos Duarte
Lana, Lucas Furtado da Fonseca, Rafael da Rocha Macedo, Tomas
Mosaner, William Murrell, Ashok Kumar, Joseph Purita, Marco Antonio
Percope de Andrade
- Published in: World Journal of Stem
Cells, 2021.
- **Summary:** This overview discusses the mechanisms
of action for PRP and BMAC and their potential synergistic effects
in musculoskeletal healing. The authors highlight that while both
therapies show promise, further research is needed to standardize
treatment protocols and fully understand their combined effects on
healing processes.
5. PRP and BMAC for Musculoskeletal Conditions via
Biomaterial Carriers*
- Authors: Fabio S. M.
Yamaguchi, Shahin Shams, Eduardo A. Silva, Roberta S. Stilhano
- Published in:** International Journal of
Molecular Sciences, 2019.
- Summary: This review focuses on
the use of biomaterial carriers in conjunction with PRP and BMAC to
enhance regenerative processes for musculoskeletal injuries. The
authors emphasize the growing interest in these therapies as
alternatives for treating cartilage, muscle, and bone injuries, and
discuss the various biomaterials used in clinical trials.
Key Takeaways:
- The efficacy of BMAC compared to PRP in various orthopedic
applications.
- Insights into the mechanisms of action and potential synergistic
effects of PRP and BMAC.
- The importance of research in optimizing treatment protocols for
knee osteoarthritis and other musculoskeletal conditions.
Upcoming Events:
Visit NRAPpain.org to learn about
the virtual pain fellowship and other educational resources.
Additionally, check out our live courses designed for healthcare
professionals looking to enhance their skills in pain management
and regenerative therapies.
Listen to the Episode:
Join Dr. Rosenblum as he provides expert analysis on these studies
and discusses the implications for pain management and regenerative
medicine.
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questions are always welcome!
Disclaimer
The content of this podcast is for informational purposes only and
does not constitute medical advice. Always consult with a qualified
healthcare provider for any medical concerns.